Gene expression of aromatase, SF-1, and HSD17B2 in menstrual blood as noninvasive diagnostic biomarkers for endometriosis
Amanda CR, Asmarinah, Hestiantoro A, et al.European Journal of Obstetrics & Gynecology and Reproductive Biology · 2024DOI 10.1016/j.ejogrb.2024.07.061
In plain language
Expression of aromatase, SF-1 and HSD17B2 in menstrual blood was compared between 20 women with confirmed endometriosis and 20 women with infertility and no visible endometriosis. All three estrogen-pathway genes were higher in endometriosis, with case-control AUCs of 0.81 to 0.98, and the authors call for larger studies to confirm them.
Key numbers
- 20 vs 20
- Women with endometriosis versus women with infertility and no visible endometriosis
- 3
- Genes: aromatase, SF-1 and HSD17B2
What it means
Estrogen-pathway genes linked to endometriosis can be read from menstrual blood. A small study, but another independent sign that shed endometrial material carries disease signal.
What it does not show
Forty women in one center, controls drawn from an infertility clinic, case-control design without a validation group; the AUCs are not test accuracy.
How to cite
Amanda CR, Asmarinah, Hestiantoro A, Tulandi T, Febriyeni. Gene expression of aromatase, SF-1, and HSD17B2 in menstrual blood as noninvasive diagnostic biomarkers for endometriosis. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2024;301:95-101. doi:10.1016/j.ejogrb.2024.07.061