DIA-based analysis of the menstrual blood proteome identifies association between CXCL5 and IL1RN and endometriosis
Ji S, Liu Y, Yan L, et al.Journal of Proteomics · 2023DOI 10.1016/j.jprot.2023.104995
In plain language
Data-independent acquisition mass spectrometry of menstrual blood from 8 women with and 8 without endometriosis found 95 differentially expressed proteins. CXCL5 and IL1RN were confirmed by ELISA as higher in endometriosis.
What it means
Mass spectrometry found inflammation-related proteins that differed in endometriosis. They are candidates for larger, prospective studies.
What it does not show
Sixteen women in a case-control discovery study; CXCL5 and IL1RN are candidates for larger prospective studies, not validated markers.
How to cite
Ji S, Liu Y, Yan L, Zhang Y, Li Y, Zhu Q, et al. DIA-based analysis of the menstrual blood proteome identifies association between CXCL5 and IL1RN and endometriosis. Journal of Proteomics. 2023;289:104995. doi:10.1016/j.jprot.2023.104995