Menstrual blood serum extracellular vesicles reveal novel molecular biomarkers and potential endotypes of unexplained infertility
Brennan K, Vaiciuleviciute R, Uzieliene I, et al.Scientific Reports · 2025DOI 10.1038/s41598-025-95818-w
In plain language
Extracellular vesicles were isolated from liquid menstrual blood collected on cycle day two from 9 fertile women and 8 women with unexplained infertility. Proteomic profiling revealed candidate biomarkers and possible endotypes of unexplained infertility from a non-invasive sample.
What it means
Vesicle proteins in menstrual blood differed in women with unexplained infertility. This is discovery research that suggests where to look, not a diagnostic test.
What it does not show
Seventeen women, liquid menstrual blood processed by ultracentrifugation, no validation set; it is discovery work, not a test, and does not use dried samples.
How to cite
Brennan K, Vaiciuleviciute R, Uzieliene I, Pachaleva J, Kasilovskiene Z, Piesiniene L, et al. Menstrual blood serum extracellular vesicles reveal novel molecular biomarkers and potential endotypes of unexplained infertility. Scientific Reports. 2025;15(1):11974. doi:10.1038/s41598-025-95818-w