Qvin researchFibroids

Differences in menstrual cytokine profiles of women with and without symptomatic uterine fibroids

Dhanani Z, Jimenez Ramirez N, Nguyen J, et al.F&S Science · 2023DOI 10.1016/j.xfss.2023.09.006

In plain language

A short report from Stanford, with a Qvin co-author, comparing menstrual blood cytokines in 7 women with uterine fibroids and 4 controls. Samples were collected on the first heavy day with a modified menstrual pad carrying a dried blood strip; four immune markers (G-CSF, IL-1α, IL-6 and VEGF-A) trended higher on average in the fibroid group, and IL-1β trended lower.

Key numbers

7 vs 4
Women with fibroids versus controls
4 up, 1 down
G-CSF, IL-1α, IL-6 and VEGF-A higher; IL-1β lower
Day 1
Collected on the first heavy day, on a dried strip

What it means

Menstrual blood may be a practical way to study the biology behind fibroid symptoms, which had not been looked at this way before. It is early research, not a test.

What it does not show

A pilot with 11 women in total that reports trends, not statistically tested differences. Much larger studies are needed before any of these markers could be relied on.

How to cite

Dhanani Z, Jimenez Ramirez N, Nguyen J, Rosenberg-Hasson Y, Naseri S, Lum D, et al. Differences in menstrual cytokine profiles of women with and without symptomatic uterine fibroids. F&S Science. 2023;4(4):339-340. doi:10.1016/j.xfss.2023.09.006

Reviewed by the Qvin science team, .