The fieldProteomics

Proteomic Analysis of Menstrual Blood

Yang H, Zhou B, Prinz M, et al.Molecular & Cellular Proteomics · 2012DOI 10.1074/mcp.M112.018390

In plain language

The first published proteome of menstrual blood, by researchers at the New York City Office of Chief Medical Examiner, using samples from healthy volunteers collected mainly on tampons. From two mid-period samples it identified 1,061 proteins, of which 385 were not found in published venous blood or vaginal fluid proteomes, supporting menstrual blood as a distinct body fluid with its own protein content.

Key numbers

1,061
Proteins identified in menstrual blood
385
Not found in published venous blood or vaginal fluid proteomes

What it means

Early evidence that menstrual blood is a distinct body fluid, not just blood. Many of its proteins fit endometrial biology: tissue breakdown, immune activity and matrix remodeling.

What it does not show

Two samples analyzed in depth and compared against other groups' published proteomes, not matched blood from the same women; it catalogs proteins and does not link any to disease.

How to cite

Yang H, Zhou B, Prinz M, Siegel D. Proteomic Analysis of Menstrual Blood. Molecular & Cellular Proteomics. 2012;11(10):1024-1035. doi:10.1074/mcp.M112.018390

Reviewed by the Qvin science team, .